DefinePK

Abstract

Cerebrovascular diseases which is called wind stoke in Chinese
medicine, happened commonly and frequently in either the community or healthcare
setting. Poststroke motor dysfunction and shortage of effective or curative
treatments bring an enormous emotional and financial burden. Ischemic cerebrovascular
ICVD disease is one of the three principal diseases causing people to death
in which seconded only to heart disease and cancer. The pathophysiological role
of platelets and coagulation is largely unclear. The currently approved drugs
of treating or preventing ICVD have significant limitations. Chinese Herbal
Medicine CHM has been an integral part of Traditional Chinese Medicine for
thousands of years. Some chinese herbs were proved to have potential benefits
on neural regeneration in cerebral ischemic injury. Many herbal formulations
have been developed and used in the treatment of ICVD and were proved to be
effective and safe. In this study, a novel text mining method was development
to explore the treatment principles more intuitively. Networks of TCM patterns
and CHMs which are most frequently used in ICVD treatment are built-up and analyzed,
two major principles are explored Promoting blood circulation to remove blood
stasis with strengthening healthy qi. These findings might guide the clinicians
in treatment of ischemic cerebrovascular.