Comparison of mean hospital stay in intravenous Immunoglobulin vs Plasmapharesis in children with gullian-barre syndrome in a Tertiary Care PICU.

Article Information

Title: Comparison of mean hospital stay in intravenous Immunoglobulin vs Plasmapharesis in children with gullian-barre syndrome in a Tertiary Care PICU.

Authors: Muhammad Shahzaib Altaf, Asim Khurshid, Imran Maqsood

Journal: The Professional Medical Journal (TPMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2022-07-01	2023-06-30
Y	2021-07-01	2022-06-30

Publisher: Independent Medical College, Faisalabad- Pakistan

Country: Pakistan

Year: 2023

Volume: 30

Issue: 7

Language: English

DOI: 10.29309/TPMJ/2023.30.07.7541

Keywords: PICUPlasmapheresisGuillain-barré syndromeimmunoglobulin

Abstract

Objective: To compare the mean hospital stay between intravenous immunoglobulin (IVIG) versus plasmapheresis in the management of children with Guillain-Barré syndrome (GBS). Study Design: Randomized Controlled Trial. Setting: Emergency and Paediatric Intensive Care Unit, Children’s Hospital and Institute of Child Health, Multan. Period: June 2021 to December 2021. Material &amp; Methods: Children aged 5-12 years of either sex presenting with GBS with duration below ≤2 weeks were included. Baseline demographic data like age, gender and duration of GBS were noted. Subjects were randomly divided into 2 groups (30 in each group) by lottery method. In Group-A, IVIG was administered for five days while in Group-B, patients received a daily one-volume plasma exchange (PE) for five consecutive days. Outcome was noted in terms of hospital stay. Results: In a total of 60 patients, there were 35 (58.3%) were female and 25 (41.7%) male. The mean age was 8.28±2.06 years while 36 (60.0%) patients were aged between 9 to 12 years. The mean duration of disease was 12.89±4.01 days. Maternal educational status of 17 (28.3%) patients was illiterate. The mean length of hospital stay in Group-A and Group B were 30.06±8.76 days and 18.71±6.43 days respectively which was significantly less (p&lt;0.001) among patients who were administered PE. Conclusion: When compared to IVIG, plasmapheresis reduced the duration of mean hospital stay and improved the recovery of children with GBS.

Disclaimer: The following sections are produced through an intensive multi-stage analytical pipeline developed by DefinePK, utilizing advanced natural-language processing, domain-specific knowledge models, and automated cross-referencing systems. Despite the rigor and computational effort involved, the generated summary may still contain inaccuracies or incomplete interpretations. Users are strongly advised to verify all critical information against the original paper and its authoritative sources.

Research Objective

To compare the mean hospital stay between intravenous immunoglobulin (IVIG) versus plasmapheresis in the management of children with Guillain-Barré syndrome (GBS).

Methodology

Randomized Controlled Trial conducted in an Emergency and Pediatric Intensive Care Unit. Children aged 5-12 years with GBS of less than two weeks duration were included. Participants were randomly divided into two groups of 30: Group-A received IVIG for five days, and Group-B received daily one-volume plasma exchange (PE) for five consecutive days. The primary outcome measured was the length of hospital stay.

Methodology Flowchart

                        graph TD;
    A["Recruit Children with GBS 5-12 yrs, <2 wks duration"] --> B["Randomly Assign to Groups"];
    B --> C["Group A: Administer IVIG 5 days"];
    B --> D["Group B: Administer Plasmapheresis 5 days"];
    C --> E["Record Hospital Stay"];
    D --> E;
    E --> F["Analyze Data & Compare Mean Hospital Stay"];
    F --> G["Draw Conclusion"];

Discussion

The study found that plasmapheresis significantly reduced the mean hospital stay in children with GBS compared to IVIG. This aligns with previous studies, including one from Egypt, which also reported shorter hospitalization times with plasmapheresis. The discussion highlights that while both treatments are effective, plasmapheresis appears to offer a more rapid recovery in terms of hospital stay.

Key Findings

The mean hospital stay in the IVIG group (Group-A) was 30.06±8.76 days, while in the plasmapheresis group (Group-B) it was 18.71±6.43 days. This difference was statistically significant (p<0.001), with plasmapheresis showing a shorter duration of hospital stay.

Conclusion

Plasmapheresis, when compared to IVIG, reduced the duration of mean hospital stay and improved the recovery of children with Guillain-Barré syndrome.

Fact Check

1. Sample Size: The study included a total of 60 patients, with 30 patients in each of the two treatment groups (IVIG and Plasmapheresis).
2. Mean Hospital Stay (IVIG): The mean hospital stay for patients treated with IVIG was 30.06±8.76 days.
3. Mean Hospital Stay (Plasmapheresis): The mean hospital stay for patients treated with Plasmapheresis was 18.71±6.43 days.

Mind Map

Loading PDF...

Loading Statistics...

DefinePK

Select Collection