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Title: A comparison of skeletal age of thalassemic patients of 9 – 15 years with chronological age by radiography.
Authors: Muhammad Saleem Akhtar, Amna Arooj, Yasmeen Batool, Muhammad Nafees
Journal: The Professional Medical Journal (TPMJ)
Publisher: Independent Medical College, Faisalabad- Pakistan
Country: Pakistan
Year: 2023
Volume: 30
Issue: 3
Language: English
DOI: 10.29309/TPMJ/2023.30.03.7056
Keywords: β-Thalassemia majorGrowth hormoneChronological AgeGrowth RetardationSkeletal Age
Objective: To compare bone/skeletal age of thalassemic children with chronological age by hand-wrist radiography to assess possible growth retardation. Study Design: Descriptive Cross-sectional study. Setting: In collaboration of Radiology & Pathology Department of Sahiwal Teaching Hospital and Ali Zaib Foundation, Sahiwal. Period: January 2021 to June 2021. Material & Methods: Three hundred and fifty patients were purposively recruited for the study. Among them 250 were registered children of thalassemia at Ali Zaib Foundation, Sahiwal and 100 were non-thalassemic children taken as control group to make comparison of the findings from thalassemia patients. After approval from institutional review board (IRB) and taking written informed consent of the parents, the researchers get their hand-wrist radiographs done. Ossification centers were evaluated to assess bone age that was compared with chronological age. Data was analyzed using SPSS-24. Results: The statically significant difference was seen in bone age between the two groups as compared to their chronological age that remained statically non – significant. Conclusion: To evaluate possible growth retardation in thalassemia children, hand-wrist X-ray can be considered a standard modality.
To compare the bone/skeletal age of thalassemic children aged 9-15 years with their chronological age using hand-wrist radiography to assess possible growth retardation.
Descriptive cross-sectional study conducted in collaboration with the Radiology & Pathology Departments of Sahiwal Teaching Hospital and Ali Zaib Foundation, Sahiwal. 350 patients were recruited: 250 registered children with thalassemia and 100 non-thalassemic children as a control group. Hand-wrist radiographs were taken, ossification centers were evaluated to assess bone age, which was then compared with chronological age. Data was analyzed using SPSS-24.
graph TD;
A["Recruit Patients Thalassemic & Control"] --> B["Obtain Informed Consent"];
B --> C["Perform Hand-Wrist Radiography"];
C --> D["Evaluate Ossification Centers for Bone Age"];
D --> E["Compare Bone Age with Chronological Age"];
E --> F["Analyze Data using SPSS-24"];
F --> G["Draw Conclusions on Growth Retardation"];
The bone age of thalassemic patients was significantly less than that of the control subjects, indicating potential growth retardation. This is attributed to multifactorial causes including chronic hypoxia, nutritional deficiencies, iron overload, and potential endocrine disturbances. Hand-wrist radiography is a viable method to assess bone age and monitor growth retardation in these patients.
A statistically significant difference was observed in bone age between the thalassemic and non-thalassemic groups. The chronological age between the two groups was statistically non-significant.
Hand-wrist X-ray can be considered a standard modality for evaluating possible growth retardation in thalassemia children by assessing their skeletal age.
1. Study Period: Data was collected from January 2021 to June 2021. (Confirmed in text)
2. Number of Thalassemic Patients: 250 registered children with thalassemia were recruited. (Confirmed in text)
3. Statistical Significance of Bone Age Difference: A p-value of 0.0002 was reported for the difference in bone age between the groups, indicating statistical significance. (Confirmed in text)
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