DefinePK

Research Objective

To report an infrequent case of a young male with retroperitoneal Angiomatoid Fibrous Histiocytoma (AFH) and emphasize that AFH may occur in retroperitoneal tumors.

Methodology

Case report detailing a young male patient presenting with left upper abdominal pain. Investigations included clinical examination, baseline blood tests, ESR, abdominal sonography, gastroscopy, colonoscopy, CT scan, Endoscopic Ultrasonography, PET scan, and biopsy with immunohistochemistry. Surgical resection was performed, followed by post-operative follow-up.

Methodology Flowchart

                        graph TD; A["Patient Presentation with Abdominal Pain"] --> B["Clinical Examination & Baseline Investigations"]; B --> C["Imaging Studies"Sonography, CT, EUS""]; C --> D["Biopsy and Immunohistochemistry"]; D --> E["Diagnosis: Angiomatoid Fibrous Histiocytoma"]; E --> F["Surgical Resection"]; F --> G["Post-operative Follow-up"]; G --> H["Assess for Residual Disease/Metastasis"]; H --> I["Long-term Monitoring"];                    

Discussion

AFH is a rare mesenchymal neoplasm typically found in the deep dermis or subcutaneous tissue of young individuals. This case highlights a rare retroperitoneal manifestation. While generally slow-growing with a good prognosis, AFH can be misdiagnosed and has a potential for local recurrence. Surgical resection is the primary management.

Key Findings

A well-defined retroperitoneal mass measuring 10.1 x 9.5 x 5.0 cm was identified in the left hypochondrium. Biopsy confirmed Angiomatoid Fibrous Histiocytoma. Surgical resection was successful, and the patient remained symptom-free with no evidence of residual disease or metastasis on follow-up.

Conclusion

Angiomatoid Fibrous Histiocytoma can manifest in the retroperitoneum, a rare location. Early diagnosis and surgical management are crucial for favorable outcomes. Strict follow-up is recommended due to the unpredictable behavior of the tumor.

Fact Check

1. Patient Presentation: The patient presented with recurrent episodes of pain in the left upper abdomen for 3 months. (Confirmed in Case Report section).
2. Tumor Size on CT Scan: The CT scan defined a retroperitoneal area of 10.1 x 9.5 x 5.0 cm. (Confirmed in Case Report section).
3. AFH Occurrence: AFH most commonly occurs in children and young adults. (Confirmed in Abstract and Introduction sections).

Mind Map