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Title: Serum visfatin levels in obese and non-obese individuals; A comparative cross-sectional study.
Authors: Irfan Younus, Shama Iqbal, Muhammad Shahid, Hamid Hassan
Journal: The Professional Medical Journal (TPMJ)
Publisher: Independent Medical College, Faisalabad- Pakistan
Country: Pakistan
Year: 2023
Volume: 30
Issue: 1
Language: English
DOI: 10.29309/TPMJ/2023.30.01.7169
Keywords: ObesityVisfatinLipid Profiles
Objective: To compare serum visfatin levels in obese and non-obese individuals. Study Design: Cross-sectional study. Setting: District Head Quarter Hospital, Gujrat. Period: July 2020 to May 2021. Material & Methods: A total of 52 subjects were included fulfilling the inclusion criteria. They were divided in two groups, 26 non-obese subjects were placed in Group A and 26 obese subjects in Group B. The serum visfatin level, Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), triglycerides (TG) were calculated in both groups. The statistical analysis was carried out using SPSS version 22.0. Results: The obese subjects had higher serum visfatin levels than the non-obese i.e. 3.87 ± 0.90ng/mL vs. 1.08 ± 0.56 ng/mL (p=0.001). A significant elevation was observed in the serum LDL level among obese subjects, 224.6 ± 55.0 mg/dl compared to 114.2 ± 22.9 mg/dl among non-obese subjects. Similarly, the serum TG levels were also significantly high among obese subjects (p=0.001). The intergroup comparison showed that the serum visfatin levels were higher among obese subjects with dyslipidemia (3.97 ± 0.93 ng/dl) than non-obese (3.46 ± 0.86 ng/dl). Conclusion: It is concluded that the serum visfatin levels are significantly high among obese individuals than non-obese counterparts.
To compare serum visfatin levels in obese and non-obese individuals.
Cross-sectional study conducted at District Head Quarter Hospital, Gujrat, from July 2020 to May 2021. A total of 52 subjects were divided into two groups: 26 non-obese (Group A) and 26 obese (Group B). Serum visfatin, LDL, HDL, and triglycerides were measured. Statistical analysis was performed using SPSS version 23.0.
graph TD;
A[Recruit 52 subjects] --> B[Divide into Group Anon-obese and Group Bobese];
B --> C[Measure serum visfatin, LDL, HDL, TG];
C --> D[Analyze data using SPSS v23.0];
D --> E[Compare visfatin levels between groups];
E --> F[Draw conclusions];
The study suggests a significant association between obesity and elevated serum visfatin levels, potentially due to increased fat deposition triggering visfatin synthesis. The findings are supported by several other studies, although some research has reported variable correlations. The elevated levels of LDL and triglycerides in obese individuals also correlate with higher visfatin levels.
Obese subjects had significantly higher serum visfatin levels (3.87 ± 0.90 ng/mL) compared to non-obese subjects (1.08 ± 0.56 ng/mL) (p=0.001). Obese subjects also showed significantly elevated serum LDL (224.6 ± 55.0 mg/dl vs. 114.2 ± 22.9 mg/dl) and triglycerides (p=0.001). Serum visfatin levels were higher in obese individuals with dyslipidemia.
Serum visfatin levels are significantly higher in obese individuals compared to their non-obese counterparts. Further prospective studies with larger sample sizes are needed to clarify visfatin's role and the mechanisms behind its overexpression in obesity.
1. Study Period: The study was conducted from July 2020 to May 2021. (Confirmed in text)
2. Sample Size: A total of 52 subjects were included in the study. (Confirmed in text)
3. Visfatin Levels in Obese vs. Non-Obese: Obese subjects had serum visfatin levels of 3.87 ± 0.90 ng/mL, while non-obese subjects had levels of 1.08 ± 0.56 ng/mL (p=0.001). (Confirmed in text)
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