DefinePK hosts the largest index of Pakistani journals, research articles, news headlines, and videos. It also offers chapter-level book search.
Title: Maternal complications in women presenting with first trimester threatened miscarriage.
Authors: Neelam Saba, Bushra Iftikhar, Mukhtiar Begum Noonari, Farzana Nasir, Nazia Hashim, Sonia Naqvi
Journal: The Professional Medical Journal (TPMJ)
Publisher: Independent Medical College, Faisalabad- Pakistan
Country: Pakistan
Year: 2022
Volume: 29
Issue: 12
Language: English
DOI: 10.29309/TPMJ/2022.29.12.7227
Keywords: MiscarriagePlacental abruptionThreatened AbortionHypertensive Disorder of PregnancyPretermbirthPPROM (preterm pre- labour rupture of membranes)
Objective: To determine the frequency of miscarriage, hypertensive disorder of pregnancy, placental abruption and preterm birth in women with first trimester threatened miscarriage. Study Design: Cross-sectional study. Setting: Department of Obstetric & Gynaecology, Sir Syed Hospital and Pakistan Naval Ship Shifa Hospital (Karachi). Period: April, 2021 to March, 2022. Material & Methods: Ninety two women 18-40 year old, diagnosed as threatened miscarriage at ≤ 13 weeks based on history, examination and ultrasound were included in the study after informed consent and followed till delivery. Women with genital infection, other form of miscarriage and multiple pregnancy were excluded. Data recorded from hospital documents. Maternal age, parity and Gestational age assessed. Miscarriage, hypertensive disorder of pregnancy, placental abruption, preterm birth and PPROM expressed as frequency and percentages. Logistic regression analysis performed. Chi square test (x2) used and P-value ≤ 0.05 taken as significant. Results: Mean age of women was 29.21±3.49 years. Mean parity was 2.65±1.15. Mean Gestational age at presentation was 7.96±1.78 weeks. 11.11%. (10/90) cases had miscarriage. 88.88% (80/90) women continued their pregnancy. 42.5% (34/80) had hypertensive disorder of pregnancy. 20% had pregnancy induced hypertension and 22.5% had pre-eclampsia. Preterm birth was seen in 26.3% (21/80). Frequency of PPROM and placental abruption was 6.3% (5/80) each. Women of 21-25 yr age were more at risk of hypertensive disorder of pregnancy than other age groups. There was no significant affect of maternal age and parity on preterm birth and placental abruption. Frequency of Preterm birth was 38.4% in women with hypertensive disorder, more than 2 times higher than non-hypertensives (17.4%) and found significant (P-value=0.043). Conclusion: Hypertensive disorder of pregnancy was the most common maternal complication observed in women who had threatened miscarriage in first trimester. Preterm birth had significant association with hypertensive disorder of pregnancy.
To determine the frequency of miscarriage, hypertensive disorder of pregnancy, placental abruption, and preterm birth in women with first trimester threatened miscarriage.
Cross-sectional study conducted in the Departments of Obstetrics & Gynaecology at Sir Syed Hospital and Pakistan Naval Ship Shifa Hospital (Karachi) from April 2021 to March 2022. Ninety-two women aged 18-40 years, diagnosed with threatened miscarriage at or before 13 weeks gestation, were included after informed consent and followed until delivery. Exclusion criteria included genital infection, other forms of miscarriage, and multiple pregnancies. Data was collected from hospital documents, including maternal age, parity, and gestational age. Maternal complications were recorded as frequencies and percentages. Statistical analysis included logistic regression and the Chi-square test (P-value < 0.05 considered significant).
graph TD
A["Recruit 92 women with threatened miscarriage"] --> B["Informed Consent & Exclusion Criteria Check"];
B -- Included --> C["Collect Data: Demographics, History, Ultrasound"];
C --> D["Follow-up until Delivery"];
D --> E["Record Maternal Complications"];
E --> F["Data Analysis: Frequencies, Percentages, Chi-square, Logistic Regression"];
F --> G["Report Findings"];
Hypertensive disorders of pregnancy are a significant risk in women with threatened miscarriage, with pre-eclampsia being a major concern. Preterm birth is also a notable complication, and its association with hypertensive disorders highlights the need for vigilant monitoring. While placental abruption and PPROM were less frequent, they remain important considerations. The study suggests that early booking and antenatal care may contribute to a lower incidence of hypertensive disorders compared to some other regions. Limitations include not correlating complications with specific risk factors for hypertension or the amount of blood loss.
- 11.11% (10/90) of women experienced miscarriage.
- 88.88% (80/90) of women continued their pregnancy.
- Hypertensive disorder of pregnancy was the most common complication, observed in 42.5% (34/80) of women, with pregnancy-induced hypertension in 20% and pre-eclampsia in 22.5%.
- Preterm birth occurred in 26.3% (21/80) of women.
- Frequency of PPROM and placental abruption was 6.3% (5/80) each.
- Women aged 21-25 years were at higher risk of hypertensive disorder of pregnancy.
- Preterm birth showed a significant association with hypertensive disorder of pregnancy (P-value = 0.043).
- Maternal age and parity did not show a significant association with preterm birth or placental abruption.
Women experiencing threatened miscarriage in the first trimester face an increased risk of miscarriage, hypertensive disorders of pregnancy, preterm birth, and placental abruption. Hypertensive disorder of pregnancy was the most prevalent maternal complication. Preterm birth demonstrated a statistically significant association with hypertensive disorder of pregnancy. Early antenatal care, feto-maternal surveillance, and vigilant monitoring are crucial for improving outcomes.
- The study included 92 women aged 18-40 years.
- The study period was from April 2021 to March 2022.
- 11.11% of the women included in the study experienced miscarriage.
Loading PDF...
Loading Statistics...