DefinePK

Research Objective

To compare the effects of submucoperichondrial infiltration of adrenaline (1:80000) versus normal saline on mucoperichondrial injuries during flap elevation, the convenience of finding the correct surgical plane, and the duration of septoplasty surgery.

Methodology

A cross-sectional study involving sixty patients with deviated nasal septum (DNS) was conducted at Faisalabad Medical University and affiliated institutions from February 2020 to August 2020. Patients were randomly assigned to two groups: Group I received submucoperichondrial infiltration with 1:80000 adrenaline, and Group II received normal saline. Mucoperichondrial injury, convenience of finding the surgical plane, and duration of surgery were assessed by the surgeon.

Methodology Flowchart

                        graph TD;
    A["Patient Selection 60 patients with DNS"] --> B["Randomization"];
    B --> C["Group I: Adrenaline Infiltration"];
    B --> D["Group II: Normal Saline Infiltration"];
    C --> E["Septoplasty Surgery"];
    D --> E;
    E --> F["Data Collection Injury, Plane Convenience, Duration"];
    F --> G["Statistical Analysis"];
    G --> H["Conclusion"];                    

Discussion

The study suggests that 1:80000 adrenaline is superior to normal saline for submucoperichondrial infiltration in septoplasty, primarily due to improved surgical plane identification and reduced surgery time. While mucoperichondrial injury rates were similar, severe injuries were more frequent in the adrenaline group, which the authors attribute to stricter inclusion criteria and potential differences in infiltration techniques.

Key Findings

There was a statistically significant difference between the two groups in terms of the convenience of finding the correct surgical plane (P<.00001) and the duration of surgery (P<.00001). Adrenaline infiltration resulted in easier identification of the surgical plane and a shorter surgery duration compared to normal saline. No significant difference was found in the rate of mucoperichondrial injury (P is .07771).

Conclusion

Adrenaline alone at a concentration of 1:80000 is significantly more effective than 0.9% normal saline as a submucoperichondrial infiltration solution for septoplasty, particularly in improving surgical ease and efficiency. Further research with different adrenaline concentrations is recommended.

Fact Check

1. Study Period: The study was conducted from February 2020 to August 2020. (Confirmed in text)
2. Number of Patients: Sixty patients were selected for the study. (Confirmed in text)
3. Duration of Surgery: Mean duration of surgery in the adrenaline group was 9.2 minutes, while in the normal saline group it was 25.3 minutes. (Confirmed in text)

Mind Map