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Title: Internal quality control of red cell concentrates in a regional blood center.
Authors: Muhammad Ali Rathore, Mommana Ali Rathore, Saadiya Mushtaq, Inaam Qadir Javed Hashmi, Abdur Rehman Hashmi, Khadeeja Tul Kubra Hashmi
Journal: The Professional Medical Journal (TPMJ)
Publisher: Independent Medical College, Faisalabad- Pakistan
Country: Pakistan
Year: 2022
Volume: 29
Issue: 5
Language: English
DOI: 10.29309/TPMJ/2022.29.05.6859
Keywords: Quality controlHematocritsPacked Red-Cell Volume
Objective: To assess the quality of the whole blood-derived red cell concentrates by measuring hematocrit. Study Design: Cross Sectional study. Setting: Regional Transfusion Center in Rawalpindi. Period: February to December 2019. Material & Methods: A total of 390 whole blood-derived red cell concentrates were included using a random sampling technique. These units were evaluated for hematocrit which is a hematological parameter using Sysmex Hematology Analyzer XP 100. The measurement of hematocrit was expressed as the mean range and standard deviation (mean ± SD) using descriptive statistics. Results: A total of 390 whole blood-derived red cell concentrates were subjected to quality analysis by measuring the hematocrit. The mean range of hematocrit was found to be 68.4 ± 4.8 g/dL. The hematocrit of 98.7% units was in compliance with standard criteria according to the American Association of blood banks which suggested it to be less than 80%. Conclusion: The results of this study showed an optimum level of conformity of the quality of whole blood-derived Red Cell Concentrates with International Standards.
To assess the quality of whole blood-derived red cell concentrates by measuring hematocrit.
Cross-sectional study conducted at a Regional Transfusion Center in Rawalpindi from February to December 2019. A total of 390 whole blood-derived red cell concentrates were included using random sampling. Hematocrit was measured using a Sysmex Hematology Analyzer XP 100. Data was analyzed using descriptive statistics.
graph TD;
A[Collect Whole Blood Units] --> B[Process into Red Cell Concentrates];
B --> C[Screen for Transfusion Transmissible Infections];
C -- Negative --> D[Exclude Hemolyzed/FFP Rich/Low Volume Units];
D --> E[Measure Hematocrit using Sysmex Analyzer];
E --> F[Analyze Data using Descriptive Statistics];
F --> G[Assess Compliance with AABB Standards];
G --> H[Report Findings];
Internal quality control of blood products is crucial for safe and effective transfusions. The study found that red cell concentrates produced in the regional blood center meet international standards, with a high percentage of units compliant with AABB hematocrit criteria. While there is no lower limit for hematocrit, a high hematocrit (>80%) can increase blood viscosity and risk of thrombosis. Variability in quality markers can be influenced by donor characteristics, storage, collection, and processing. Periodic monitoring of quality indicators across the transfusion chain is recommended.
The mean hematocrit of the 390 red cell concentrates was 68.4 ± 4.8 g/dL. 98.7% of the units (385 out of 390) complied with the American Association of Blood Banks (AABB) standard, which suggests hematocrit should be less than 80%. Only 1.3% of units (5 units) exceeded this threshold.
The majority of whole blood-derived red cell concentrates produced in the studied setting have hematocrit levels that conform to international guidelines, indicating good quality.
* Study Period: February to December 2019. (Confirmed in text)
* Number of Units Tested: 390 whole blood-derived red cell concentrates. (Confirmed in text)
* Percentage of Compliant Units: 98.7% of units were in compliance with AABB standards. (Confirmed in text)
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