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Abstract

AbstractObjective: To compare the corneal endothelial cell density (ECD) in low, moderate, and higher myopes.
Methodology: This comparative cross-sectional study included 129 non-pathological eyes (43 eyes in each group; mild, moderate, and high myopes) and was conducted at Mayo Hospital, Lahore from May 2018 to May 2019. Patients with refractive errors other than myopia like nystagmus, strabismus, ocular and systemic pathologies were excluded. Patients with myopia up to -15D were included in the study. Corneal ECD was measured by non-contact specular microscope.
Results: Mean age of subjects was 24.82±6.712 years (females: 23.63±5.36 years; males: 26.24 ±7.84 years). Mean spherical equivalent of mild, moderate, and high myopes were -1.22 ± 0.74 D, -3.95 ± 0.64D and -9.46 ± 3.09 D, respectively. The mean corneal ECD was 2829.47±168.014 cells/mm2, 2774.12±243.27 cells/mm2 and 2668.56±216.45 cells/mm2 (p<0.001). A statistically non-significant difference was found between mild and moderate myopes (mean difference of 55.35 cells/mm2; p=0.448) while significant difference was found between mild and high myopic ECD (mean difference 360.91 cells/mm2; p <0.001). There was a moderate negative correlation between ECD and age and high myopes.
Conclusion: There was a non-significant difference in corneal ECD in low and moderate myopes. Whereas significant difference was found in mild and high myopes. Corneal ECD found to be decreased more in higher myopes as compared to low and moderate myopes.Key words: Cornea, corneal endothelial cell density, myopia.