DefinePK

Abstract

Objectives: Investigating the Adverse effects of non-branded soft drink on therenal histology in an albino rat model. Study Design: Experimental study. Place and Duration:Department of Anatomy, Isra University, in collaboration with Animal House, Department ofAnimal Husbandry and Veterinary Sciences, Sindh Agriculture University Tando Jam over sixmonths duration 2014. Methodology: A sample of 30 adult Wistar albino rats of was selectedaccording to criteria. Animals were randomly divided into 3 groups. Group A (n=10) controlrats, Group B (n=10) control rats given normal diet (12 hours fasting) and Group C (n=10)experimental rats. 3- 5 μ thick renal tissue sections were prepared, stained with H & E andexamined by light microscopy. Data was analyzed on statistical software SPSS 21.0 ver(IBM, incorporation, USA) at 95% (α)-level significance was taken at P-value ≤ 0.05. Results:Experimental group C showed an increase in kidney size and weight observed even after 12hours of fasting (P=0.0001). Histological examination of experimental kidneys show gapingBowman`s capsules, interstitial edema, glomerular distortion, calcifications, acidophilichyalinization of renal tubules, vacuolization of epithelial cell, pyknotic nuclei and necrosis.Epithelial cells revealed fragmentation and sloughing in experimental rat kidney. Conclusion:The present study reports deleterious adverse effects of non-branded soft drink on the renalhistology in an experimental albino rat model.