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Abstract

Purpose: To compare efficacy of different doses of intravitreal triamcinolone on the best correctedvisual acuity and assess the safety of the drug. Materials and methods: The study was carried out at Al-Shifa TrustEye hospital Rawalpindi, and Rawalpindi General Hospital Rawalpindi. 99 eyes of 99 patients with clinically significantmacular edema were randomized to treatment with 2mg, 4mg, 6mg and 8mg of intravitreal triamcinolone.19 patientswere lost in the follow up. Follow up of the patients was scheduled for twenty four weeks to assess the changes in thebest corrected visual acuity and the side effects of the drug such as rise in intra ocular pressure between the fourgroups. Results: There was a significant improvement of best corrected visual acuity in all the four groups. The meanBCVA improvement in the 8mg was higher than the 2mg group with an improvement of 2 lines and 1 line respectively.(P=0.04). the rise in the intra ocular pressure (>21mg) occurred in 5%, 5%, 5% 40% in the 2mg, 4mg,6mg and the 8mgrespectively. Conclusions: The higher doses of intravitreal triamcinolone may increase and prolong the visual benefitsin cases of clinically significant macular oedema but the rise in intra ocular pressure remains an area of concern. Morestudies are required to assess the optimum dose of intravitreal triamcinolone.