DefinePK

Abstract

Asthma, a chronic inflammatory disorder, prevalence is high in all ages,characterizes by cough, dyspnea, chest compression, wheezing and considerable impairmentin physical activities. Study Design: An interventional study. Objectives: Observe improvementin pulmonary functions, symptoms& quality of daily life with safety profile in chronic moderatepersistent asthma. Place & Duration: Approved with BASR University of Karachi and conductedwith the participation BMSI (Pharmacology), JPMC & Eastern Medicine HMU, Karachi. Method& Materials: Total 120 diagnosed with objective signs of reversibility, by measuring at least12% increase in FEV1, after 15 minutes with an inhalation of 200 microgram (μg) Salbutamol ofasthmatic patients were registered & divided in two groups.Group-A treated with oral Borage1.3 gram once plus Echium seed oil 500mg twice daily & Group B treated with Borage 1.3 gramonce plus Echium seed oil 500mg twice along with oral Bambuterol 10mg once daily for 90days, results of Spirometry, PEFR, daily dairy symptoms card and clinical questionnaire werestatistically evaluated, to estimate the improvement and compliance of the drugs. Results:Borage & Echium treated groups from baseline to day-90, FEV1 mean 1.30+0.02 (L) change of4.7%, FVC mean 2.3+0.3 increase of 2.19%, PEFR mean 186.3+34.1 (L/mints) change 4.1%.In group-B, FEV1 mean 1.5+0.3 increase of 13.3%, FVC mean 2.5+0.4 increase of 9.2%, PEFRmean 215.8+50.3, change of 15.2%, results are highly significant. Symptoms of daily dairycard in both group shows improvement, and reduction in night sleep awakening and clinicalquestionnaire shows improved symptoms, decreased need of recue medicine at day-90.Conclusion: Combination therapy, provided synergistic effect, to reduce the severity, improvesymptoms, quality of life along with the safety profile, results are highly significant.