DefinePK

Abstract

The herbal use for medical purposes is increasing world over. Aloe vera is onesuch herb with established anti-inflammatory action. It has great prospect in terms of replacingtraditional NSAIDS due to better side effect profile on gastrointestinal tract but its effect onplatelet aggregation is what needs to be determined. Objectives: This study was designed tosee the concentration dependent action of Aloe vera gel on platelet aggregation. Study Design:Comparative study. Setting: Post Graduate Medical Institute Lahore, Children Hospital Lahore.Duration of Study: One Year. Methodology: This study was conducted on healthy volunteersselected from staff and students of Ameer-ud-din Medical College. After determining baselineHb and platelet counts, PRP was prepared and then incubated with 2 different concentrationsof Aloe vera low (AVL) and Aloe vera high (AVH) for 30 minutes. Aggregation was stimulatedby adding the agonist arachidonic acid. Light transmission aggregometer was used to recordplatelet aggregation activity graphically for 3 minutes. Results: The data was analyzed usingSPSS version 20. Kruskal Wallis H test was performed to compare the platelet aggregation,which revealed that platelet aggregation with AVL and AVH were statistically significantly lower,amounting to 25.89% and 16.72% respectively as compared to 88.28% observed with control.Conclusion: This study has established in vitro anti-platelet effect of Aloe vera which is dosedependent.