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Background Osteopenia or osteoporosis translates as porous bones or when the holes between bone become bigger, making it fragile and liable to break easily. Practically, osteoporosis is translated to Bone Mineral Density BMD. Aged women are in higher risk due to amenorrhea, higher calcium loss in urine, immobilization, low mineral supplementation and absorption. Some antinutritive factors such as phytate accumulates in the seeds wheat, maize, rice, soya bean, etc during the ripening period. The unique structure of phytic acid offers it the ability to strongly chelate with cations such as calcium, magnesium, zinc, copper, iron and potassium to form insoluble salts. It therefore adversely affects the absorption and digestion of these minerals and consequently affects bone formation in monogastric animals and human because they lack the intestinal digestive enzyme phytase. Foods supplementation of some enzyme such as phytase and acid phosphatase in diets results in increase in mineral absorption. Phytase and acid phosphatase are two enzymes produced by some Lactobacillus bacteria, L. reuteri. Objective The current study was to investigate the valuable effect of dairy product yoghurt enriched with phytase producing bacteria in improving mineralization of bone in postmenopausal women. Methodology Two enzymes phytase and acid phosphatase have been collected from Lactobacillus reuteri. Both enzymes activity were evaluated in stored yoghurt for 11 days to estimate the duration of enzyme activity. Twelve patients proved to have either osteopenia or osteoporosis were enrolled in the study. Patients accepted to eat our dairy product for 2 months, with diet rich in grains. They gave full data about their nutritional habits. They provided blood samples and carried out DEXA for estimation of BMD at the start and end of the study period. Results The study showed that both enzymes, phytase and acid phosphatase were active for long time and wide range of acidity suggesting high activity in both stomach and intestine. The DEXA showed improved BMD in patients under investigation, elevation in serum mineral concentration and elevation of serum antioxidants markers also were demonstrated. Conclusion The study concluded that consumption of our dairy product may be promising treatment for patients having bone fragility.

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