DefinePK

Abstract

ABSTRACT


Six mature female Baladi goats were selected from Abou
Rawash experimental farm, National Research Center, Egypt, during the
period from August 2005 to January 2006. These animals divided to three
groups each of them two animals, the first keep as control, the second
has orally administered low dose of dioxins 113 and 127 LD50
and the third has orally administered high dose of dioxins 13 and 16
LD50. Milk and blood samples were collected after 48 and 96
h from dioxins exposure and after 96 h for protein fractions, to investigate
the effect of dioxins on the physical, chemical and bacterial properties
of goats milk, casein, whey protein fractions and blood picture. After
16 days, two of the goats were slaughtered and samples of the mammary
gland were taken for analysis of dioxins residues. The results indicated
that the gross chemical composition of goats milk with low dioxin doses
had higher effect than the high dioxin doses as compared to control samples,
especially for fat contents 71 and 65, respectively. The average percentages
of dioxins excretion in milk were 0.0015 and 0.0010 for low and high dioxin
doses, while the percentages storage of dioxins in the mammary gland were
0.0011 and 0.0012 for low and high dioxin doses. Goats exposed to dioxins
revealed significant decrease in total RBCs count and MCV indicating anemia.
Also, the same significant decrease in total WBCs count associated with
neutropenia. Goats exposed to dioxins revealed positive result by CMT
test after 96 h post-treated. The results of bacteriological examination
showed positive result only with the positive milk samples by CMT after
96 h the isolates were Streptococcus dysagalactiae and E. coli
which were the most prevalent isolates indicate the presence of environmental
mastitis. Generally, the oral ingestion of goats with dioxins resulted
in different patterns of milk protein fractions in casein and whey proteins.
Several bands were observed for dioxin low doses than dioxin higher doses
in most fractions of casein and whey proteins.

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