DefinePK

Abstract

<jats:p>Diazepam as a Pre-anesthetic with Propofol or Ketamine HCl has vital combinations for the induction of anesthesia in dogs. The main objective of the study was to provide cost effective and safest injectable anesthetic cocktail for induction of anesthesia in dogs and to evaluate undesired effects on liver and kidneys of the anesthetic agent. Experimental dogs (n=12) were placed equally in two groups (A and B). Each animal from group A was administer Diazepam with Propofol blend while that of group B was given Diazepam with Ketamine HCl. Orchidectomy was performed as per standard protocols for considering as a pain module. Physical parameters like temperature (P&gt;0.05), pulse (P&lt;0.05) and respiration (P&lt;0.05) and Biochemical parameters like renal (P&gt;0.05) and liver functioning test (P&lt;0.05) were performed. This research reveals that Diazepam with Ketamine HCl depicts better results over Diazepam with Propofol. It can be concluded that Diazepam with Ketamine HCl shows a safe, cost effective, ideal and easily obtainable anesthesia with least drastic hazards over kidney and liver. So, Diazepam in combination with Ketamine HCl can be used for induction of anesthesia and to execute major as well as minor surgical exercises on dogs.</jats:p>