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Abstract

Goniothalamin is a biologically active styrylprone extracted from Goniothalamin tapis Miqo. It is a non-steroidal anti-implantation agent. In this experiment, the effects of goniothalamin on rats' behavior were investigated. The parameters studied were ingestional behavior (water and food intake) and "general @ overall" behavior (e.g., aggressive and ataxia). The subjects consisted four groups of 24 female albino rats each, aged 100-day old and weighed between 180-230 gms. The animals were kept under uniform laboratory conditions throughout the experimental period and food and water were given ad. lib. The behaviours of rats were studied from a control group and three groups which were treated with goniothalamin at the doses of 10 mg/kg, 35 mg/kg, and 139 mg/kg body weight via oral route. The control group was given distilled water. Goniothalamin was administered every 21 days for 6 months to the first group of rats (4 subgroups - 6 rats each group). The second group was tested for water intake and the third group for food intake. Data were analyzed using one way ANOVA and Scheffe post hoc test. Observations of the rats' behaviors showed no significant changes in their overall behavior. Similarly, test on the ingestional behavior also showed no significant difference in water and food intake between experimental groups and the control group.