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Abstract

A study was carried out to analyze the hepatotoxicity induced by administration of gentamicin by analyzing liver specific parameters like alanine amino transferase, aspartate amino transferase, superoxide dismutase, blood urea nitrogen and creatinine in rats and to confirm the same by histopathological examination. An attempt was also made to study the possible hepatoprotective effect of Terminalia chebula on gentamicin induced toxicity and compare the same with that of silymarin. The results of this study showed that gentamicin administered at a dosage of 80 mg/kg b.wt. i/p once daily for seven days produced significant elevation of serum biochemical parameters like ALT, AST with significant reduction in the level of total protein and albumin. Administration of aqueous extract of Terminalia chebula significantly restored these parameters. The results of the present study have suggested that Terminalia chebula plant extracts can be used as a protective agent in gentamicin induced hepatotoxicity.