DefinePK

Abstract

A four year old healthy male Labrador retriever was presented at the Emergency Critical Care Unit at Madras Veterinary College, Chennai with a haemostatic disorder due to anticoagulant rodenticide toxicity. Buccal Mucosal Bleeding Time (BMBT), Prothrombin time (PT) Activated Partial Thrombo- plastin Time (APTT) were severely increased. The recent use of an antico- agulant rodenticide containing brodifacoum by the neighbours was investigated. The dog exhibited signs of moaning, muscle twitching, mild seizures, severe distension of abdomen, epistaxis, hemoperitonium, hemoptyis, hematemesis and melena. The animal did not respond to Vitamin K doses and succumbed to severe bleeding due to the brodifacoum trigger causing severe secondary haemostatic disorder and death in spite of all emergency efforts to control bleeding.