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Abstract

Investigation of ethanolic and petroleum ether extracts from the Murraya koenigii fruits (MKF) for their anthelmintic activity against Indian earthworm (Pheretima posthuma). Four concentrations (50, 100, 150 and 200 mg/ml) of each extracts were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Piperazine citrate (15 mg/ml) was taken as a reference standard drug and distilled water as control. When the dose of extract gradually increased Murraya Koenigii shows gradual increase in anthelmintic activity characterized by paralysis of earthworm and its death. The ethanolic extract showed better anthelmintic activity as compared with petroleum ether extract. From the results of the present study, it concluded that the ethanolic and petroleum ether extracts of Murraya koenigii fruit possesses anthelmintic activity. The present study is further supported by isolation of two carbazole alkaloids from fruit extract which may be responsible for the anthelmintic activity.