DefinePK

Abstract

Context: Psoriasis is a common, immune-mediated, multifactorial disease characterized by phenotypic diversity and genetic heterogeneity. Aim: The objective of this study was to evaluate the effect of Commiphora mukul on psoriasis. Materials and Methods: Six female Balb/C mice per group of which, the first three groups served as untreated, disease controls and standard (0.1% dexamethasone) respectively. Animals of groups 4, 5 and 6 were applied 0.5, 1 and 2% of the C. mukul extract on both the ears, respectively. Dermatitis was induced in mice by the application of oxazolone 1.5% (100 µL in ethanol) to the abdominal region for a period of six days. Starting seven days following sensitization, 20 µL of oxazolone 1% in a mixture of acetone and olive oil (4:1) was applied to both sides of the mouse ear on days 7, 10, 13 and 16. For detailed time-course analysis of ear swelling reactions, ear thickness was measured before sensitization phase (day 7) and after each elicitation on days 10, 13, 16 and 19. Results: C. mukul potently suppressed ear swelling at each time-point. The suppressive rates of C. mukul at concentrations of 0.5, 1 and 2% were 47.3, 55.4 and 62.2% on day 16, respectively as compared to the disease control. Microscopic examination revealed a relatively swollen ear in the disease model as compared to the control animals. Whereas condition was gradually improved in treated groups dose-dependently. Conclusion: The results suggest that C. mukul improves chronic inflammatory skin disorders.