DefinePK

Abstract

Carbendazim is a fungicidal agent for protecting farm commodities locally but its usage is usually restricted by its associated toxic potential especially when consumed by malnourished wild birds on farm. In this study, we observed the effect of protein-energy malnutrition on the histo-architectural and plasma biochemical changes associated with carbendazim toxicity in adult male Japanese quail. Carbendazim was administered at a single dose of 400 mg/kg by gastric gavage to quails fed two varied diets (Normal Protein-energy and Low Protein-energy diets). The control group received corn oil (vehicle) at 1 ml/200g body weight. The animals were sacrificed on day 8 post administration. Results showed that the relative weight of the gizzard significantly increased (P<0.01) in the Low Protein-energy diet-Oil (LPO; Control) treated group compared to the Normal Protein-energy diet-Carbendazim- (NPC) treated groups. Also, the relative weights of the liver and spleen markedly increased (P Carbendazim, malnutrition, liver, kidney, Japanese quail