DefinePK

Abstract

This study was aimed determineted level of hematological, biochemical, histological value at to may developing toxical effect of kidney nephron and effect oksidatif damage role at possible to may developing tubuler dejeneration this toxic effect with an effect of minority and majority of Zn which known antioxidant after administration of gentamicin. Eight groups were established there are 8 rats in every groups. The acute renal failure groups received 100mg/kg gentamisin ip injection daily for 8 days. Zinc deficient group was given zinc deficient diet and deiyonized water for 4 weeks. Zinc excess group was given combineted with water 227 mg/l ZnSO4 for 2 weeks. Acute renal failure + Zn excess group was given combineted with water 227 mg/l ZnSO4 for 2 weeks and 100 mg/kg gentamicin for 8 days by ip injection. Acute renal failure + Zn deficiency groups was given zinc deficient diet and deiyonized water for 4 weeks and 100 mg/kg gentamicin for 8 days by ip injection. Chronic renal failure group was applied ip 50 mg/kg gentamisin for 15 days. Chronic renal failure + Zn excess group was given combineted with water 227 mg/l ZnSO4 for 2 weeks and 50 mg/kg gentamicin for 15 days by ip injection. The result of analysis after blood and kidney tissue samples were collected, MDA concentration in the blood decreased at Zn excess group, increased in other groups as control groups. GSH concentration in the blood decreased in all groups as control group. MDA level in kidney tissue decreased in acute renal failure + Zn excess group, chronic renal failure + Zn excess group and Zn excess as control group and increased in other groups as control groups. GSH level in kidney tissue increased in acute renal failure + Zn excess group, chronic renal failure + Zn excess group and Zn excess as control group and decreased in other groups as control groups. GSH-Px level in kidney tissue increased Zn excess group but decreased in other groups as control groups. XO level in kidney tissue decreased Zn excess group but increased in other groups as control groups. EPO level in serum increased at acute renal failure + Zn excess, Zn excess groups, This level at chronic renal failure+ Zn excess group same, decreased in other groups as control groups. HCT level increased at Zn excess group, decreased at other group as control group. As a result Zn supplementation may beneficial at person with renal failure.