DefinePK

Abstract

The effects of the combination of ketamine (5mg/kg i.m.)–medetomidine (0.015mg/kg i.m.) and ketamine (5mg/kg i.m.)–medetomidine (0.01mg/kg i.m.)-morphine (0.3 mg/kg i.v.) anesthesia on clinical and hematological parameters were evaluated in twelve goats. Onset of skin analgesia and total duration of skin analgesia and duration of recumbency were measured. Rectal temperature (RT), heart rate (HR) and respiratory rate (RR) were recorded pre anesthesia and 15, 30, 60, 90 minutes intervals. Pre injection blood samples were obtained and at 15, 30, 60, 90 minutes interval during anesthesia in EDTA bottles and later analyzed. Group 1: onset of skin analgesia 18.62±4.18 min, duration skin analgesia 50.66±3.40 duration of recumbency 108±12. Group 2: onset of skin analgesia 19.62±3.18 min, duration skin analgesia 48.66±4.40 duration of recumbency 102±11.The ketamine-medetomidine combination produced a significant decrease in HR and RR values from 30 to 60 minutes compared with baseline value. PaCO2 increased significantly at 30, 60, 90 mins and PaO2 decreased significantly at 30, 60, 90 mins compared with baseline value. Cl, HCT, WBC, LYM, HGB, MCHC decreased significantly and others were no significant differences compared with baseline values. The ketamine-medetomidine-morphine combination produced a significant decrease in HR and RR same as first group. PaCO2 increased significantly at 15 minute and PaO2 increased significantly at 15, 30 and decreased 60, 90 mins compared with baseline value. Cl, HCT, WBC, LYM, MID, HGB, decreased and MCHC increased significantly differences compared with baseline values. The both of combination produced effective anesthesia and immobilization in goats. The clinical findings of this study, as hypoxemia and bradycardia were important records that may prevent from the use of the combinations in critical and cardiovascular compromised patients.