DefinePK

Abstract

The study was designed to investigate chromium (Cr) uptake by plants, hypoglycemic effect of the organic trivalent Cr(3+) on sreptozotocin (STZ)-induced diabetic mouse and the accumulation efficiency of Cr from dietary inorganic-Cr(3+), yeast-Cr, Cr-picolinate and organic-Cr(3+) in rabbit tissues. Radish sprouts was grown in the presence of Cr rich liquid fertilizers (Cr-gluconic-1, Cr-gluconic-2, Cr-picolate, Cr-glutamate and Cr-glycine). In addition, soybean, mung bean and alfalfa were also cultivated using Cr-glycine and Cr-picolinate liquid fertilizer to study the efficiency of Cr(3+) uptake. Sreptozotocin (STZ)-induced diabetic mouse were administrated organic-Cr(3+) for10 days and examined their blood glucose level. On the other hand, rabbits were allowed to take 200 ?g/head/day of CrCl3.6H2O, yeast-Cr, Cr-picolinate or organic-Cr supplemented in diets for 14 days. Body weight, liver and kidney weight, and accumulation of Cr in blood, kidney and liver were examined. Radish sprouts uptake hexavalent Cr (Cr6+) in case of all liquid fertilizer, but the mung bean was grown with Cr-glycine liquid fertilizer without uptake of Cr (6+). Mung bean grown with Cr-glycine liquid fertilizer uptake a higher (P<0.05) level of organic-Cr(3+). The dietary organic-Cr significantly (P<0.05) reduced blood glucose level in STZ-induced diabetic mouse. The administration of organic-Cr(3+) was safety for rabbit and Cr accumulation was higher (P<0.05) in the rabbits fed organic-Cr(3+) diet compared to other Cr supplements. The sequential order of the Cr accumulation in serum, kidney and liver of these rabbit were inorganic-Cr<yeast-cr<cr-picolinate<organic-cr(3+). the study concludes that mung bean plants grown with Cr-gly liquid fertilizer may uptake non-toxin organic-Cr3+ potentially which have hypoglycemic effect and be considered as a safe excellent element for animal physiology compared to any other Cr supplements.