DefinePK

Abstract

An eight-month-old German shepherd dog was presented for disseminated exophytic papillomatosis affecting the oral mucosa. Grossly, the lesions appeared as white pedunculated cauliflower-like masses in the gingival and oral cavity. Histology of biopsy revealed hyperkeratosis of the stratum corneum, spinous layer hyperplasia, koilocytes, giant keratohyaline granules and basophilic intranuclear inclusion bodies which were consistent with Canine papillomatosis. Treatment with oral acyclovir three times daily for 10 days without any attempt to surgically de-bulk the lesions, allowed for reduction and complete regression of papillomatosis with no adverse effects between days 5 and 10 respectively. This study concludes that acyclovir is an effective and safe option for the treatment and management of canine papillomatosis.