DefinePK

Abstract

Canine parvovirus enteritis (CPV) is one of foremost reasons of vomiting and diarrhea in puppies with consequential alterations in homeostasis; anemia is one of these major changes. This investigation aimed to study alterations in Hepcidin and clinic-pathologic parameters in CPV infected puppies. This investigation carried out thirteen puppies with CPV enteritis and five clinically healthy puppies were enrolled as control with total number of 18 puppies. Upon admission, clinical signs were recorded and rapid in-clinic IC test kit for detection of CPV Ag in feces. Blood samples were used to determine hematologic and biochemical alterations along with hepcidin level. Vomiting and diarrhea were the main recorded clinical signs. Significant reduction in erythrogram and leucogram were recorded in CPV infected puppies. A reduction in Total Protein and albumin accompanied with elevation in triglycerides and Blood Urea Nitrogen were recorded. Significant elevation in serum hepcidin values in CPV enteritis when compared to control data was recorded. Depending on obtained results, CPV enteritis is associated with elevation in hepcidin level, anemia, reduction in leucocytes and elevation in triglycerides.