DefinePK

Abstract

Research goal was obtaining of ant stress, ecologically clean preparation with high bio-accessibility (bio-digestibility) and low toxicity intended for oral administration, and determination of prospects of its use in the area of live-stock farming (namely pig breeding). Manufacturing method of mentioned preparation is elaborated, which foresees the use of freshly-prepared iron carbonate paste synthesized via interaction of FeCl2·4H2O and NaHCO3 as a source of main active component – Iron (II); interaction of iron carbonate and cobalt chloride with complex formation with monosaccharide D-Fructose having hemo-stimulating properties; concentrating of complex solutions up to syrup consistency; its extraction from reaction area in the free state using alcohol-ether mixture, its treatment with acetone, ether, and drying in vacuum conditions; infraction of complex mixtures containing certain quantities of Fe(II) Fructose and Co(II) Fructose with aqueous Askan-clay (through ultrasonic material dispersion); preparation of water suspension, its drying, grinding, manufacturing of solid form of preparation for oral administration. The preparation manufactured by mentioned method contains (in mass %): Fe(II)- Fructoze 15.75-31.6, [Fe(II)- 3.75-7.50], Co(II)-Fructose 0.28, [Co(II)-0.07], natural Askan-clay 68.2-36.5. The offered method provides getting of highly digestible, functional targeted product with maximum content of Fe(II). Therapeutic and preventive efficiency of manufactured preparation was tested on animals under study, namely on store pigs (toxicity of preparation was preliminary tested on laboratory white rats). Experiment result was expressed in getting rid of complications (iron deficiency anemia, diarrhea-dyspepsia) caused by stress factors related to termination of breast feeding of store pigs and food change, as well as in their normal growth and development, normal blood chemistry values and live weight gain.