DefinePK

Abstract

On a field level among poultry flocks, the efficacy of the most common antibiotics against Mycoplasma species was decreased, Hence the traceability of the new updates about the minimum inhibitory concentration becomes very important for veterinarians in fighting antibiotic resistant strains circulating among birds. In the current study the minimum inhibitory concentrations (MICs) of the common anti-mycoplasma drugs as enrofloxacin, difloxacin oxytetracycline, doxycycline, chlortetracycline, tylvalosin, erythromycin, tylosin, tilmicosin, spiramycin, tiamulin, lincomycin, spectinomycin and dihydrostreptomycin against MG and MS isolates of broiler and layer chickens in Egyptian farms and recorded in GenBank. The recovered results showed that till now the tylvalosin macrolides is the most efficient drugs in the control of mycoplasmas as it has the lowest MICs value against local M. gallisepticum and local M. synoviae as tylvalosin at dilution rate of 0.001-2?g/mL, showed the lowest values among the studied antibiotics as MICs value were 0.001,0.005 and 0.008?g/mL against MG and 0. 2,0.25 and 0.5?g/mL against MS strains.