DefinePK

Abstract

The study focused on immunological responses to vaccines in laboratory rabbits. It aimed to explore the development and longevity of immunological memory. Two vaccine types, live attenuated and inactivated, were compared, specifically for myxomatosis and viral hemorrhagic disease in rabbits. Following vaccination, animals exhibited a significantly higher antibody titer against inactivated viral hemorrhagic disease compared to live attenuated myxomatosis. The body’s primary response to viral pathogens involved an increase in segmented neutrophils, indicating cellular activation. Starting from days 7-14, serum antibody levels increased, peaking within the first month post-vaccination and declining within 9-12 months, dependent on the pathogen source. The rate of antibody increase was influenced by booster dose timing, with shorter intervals resulting in higher intensity antibody production. Overall, this research informs vaccination strategies and immunological memory.