DefinePK

Abstract

Background:   Sexual dysfunctions are often associated with oxidative stress, DNA damage, and reduced levels of sex hormones. Methods : In this study, a combination of polyfloral honey, royal jelly (RJ), Korean ginseng, and palm pollen were tested to reduce oxidative DNA damage in semen. The study involved 25 male patients aged 22-45 years who were participating in a fertility clinic in Wasit, South-East Iraq .  Surgically resolvable problems were excluded, as well as subjects who smoked. Results :  Semen analysis and serum total oxidant status were used to assess the fertility potential in males, and pregnancy occurrence served as evidence of sperm ability for fertilization. Our findings indicate that consuming honey with Korean ginseng and palm pollen improved sperm count by reducing caspase-3 activity and protecting against oxidative DNA damage. In addition, forward progressive motility and morphology of the sperm were significantly improved by the treatment and also had a direct effect on mitochondrial enzymes. Conclusion : Therefore, the use of honey combined with specific herbals appears to be a promising treatment option  for the  improvement of sperm parameters to treat male infertility. Keywords: Antioxidants; Oxidative DNA damage; Honey; Royal jelly; Korean ginseng; Post-acrosomal lamina