DefinePK

Abstract

Background:   Rice is an essential component of the diets of people all over the world, and it accounts for a sizeable amount of the calories that they consume. The world's food supply suffers huge economic losses due to fungal deterioration on rice seeds. The medicinal plant  Saussurea costus  contains bioactive chemicals and is well-known for its many therapeutic uses. There are a number of species of  Aspergillus  that are considered to be diseases in vegetables and fruits. One of these species is  Aspergillus niger . The purpose of this current investigation was to investigate the impact of the crude Alkaloid, Flavonoid, and Terpenoid chemicals derived from  Saussurea costus'  roots on Aspergillus species Purified from Rice seeds obtained from various markets in Hillah, Iraq. Methods:  In vitro, antifungal activity against  Aspergillus  species was achieved using the food poisoning method. Three concentrations 5, 10, and 15mg/ml of each crude compound were prepared and compared to a positive control represented by Carbendazim500g/l and a negative control represented by 10% dimethyl sulfoxide. Results:  An objective of the current investigation was to manage the  Aspergillus  species growth identified in Rice seeds by utilizing secondary compounds derived from the roots of  Saussurea costus . The study's data indicated that the extracts represented by active compounds such as Alkaloids, Flavonoids, and Terpenoids obtained from  Saussurea costus  roots exhibited a significant decrease in the of  Aspergillus  species growth, particularly at a concentration of 100mg/ml, in contrast to the negative control. This effect was equivalent to that of the positive control, Carbendazim 500g/l. Conclusion:  Finally,  Saussurea costus  roots have shown the most efficacy in controlling  Aspergillus  species, particularly through the presence of Alkaloid, Flavonoid, and Terpenoid chemicals at a concentration of 100mg/ml. Keywords: Antifungal activity;  Saussurea costus ; Alkaloids; Flavonoids; Terpenoids