DefinePK

Abstract

In this paper, a mathematical modeling concept is used to analyse the glucose-insulin interaction in managing Type 1 Diabetes Mellitus (T1DM). The Hovorka model has been chosen to design the glucose kinetics, so that the relationship between reactions of insulin to blood glucose concentration can be observed. This mathematical model implements a nonlinear ordinary differential equation where each parameter represents specific functions. The meal and exogenous insulin bolus are the two inputs in this mathematical model for prediction of glucose levels. The analysis of this model is done by using C++ programming language which is the first step towards system-on-chip (SoC) implementation for real time simulation based analysis of glucose-insulin dynamics.