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Abstract

Electrical-based biosensor application in the medical application systems bring advantage in terms of fast responsive time of disease detection and with low cost production i.e. compatible with CMOS technologies. In this paper we present the interdigitated electrode (IDE) for detection of cardiac troponin biomarkers. IDE device is fabricated and followed by titanium dioxide (TiO2) thin film deposition on the IDE surfaces using sol-gel method, acts as a sensing area. TiO2 nanoparticle not only provide high surface to volume ratio and chemically-environment-dependent electrical properties, but it also promotes natural oxygen group bonding that is crucial for biomolecule linkage. After that, the TiO2 surface undergo surface functionalization process to allow the reaction of antigen-antibody protein. Surface morphology is characterized by using Atomic Force Microscope (AFM) and Scanning Electron Microscope (SEM). For electrical characteristics after hybridication, the IDE is characterized using Semiconductor Parameter Analyzer (SPA). Result shows that, our IDE device is capable to detect troponin-I protein biomarkers.