DefinePK

Abstract

With the advancement in microfluidic technology, fluid flow control for syringe pump is always essential. Precise fluid flow in microfluidic device would able to perform emulsion and well-mixed fluid. In this paper, a mechatronic syringe pump has been developed and customized to control the high fluid flow in a poly-dimethylsiloxane (PDMS) microfluidic device based on a polyimide laminating film. The syringe pump was designed to drive continuous fluid in a polyimide based microfluidic device at flow rates of 1 - 5 ml/min. The electronic system consists of an Arduino microcontroller board and a uni-polar stepper motor. The program designed to control the rotation speed of the stepper motor was also discussed in this paper. As the motor rotates, the plunger pumps the liquid out of the syringe. The accuracy of the fluid flow rate was determined by adjusting the number of micro-step/revolution to drive the stepper motor to infuse fluid into the microfluidic device. The microfluidic device was made of polydimethylsiloxane to increase sealed convalently to the adhesive polyimide. With the precise control of the electronic system, the syringe pump could accurately inject fluid volume at 1- 5 ml/min into a microfluidic device.