DefinePK

Abstract

A fatty acid amide has been made from diethanolamine and glucosamine using Novozyme 435 lipase in organic solvents. Fatty acid amide is a surfactant that is widely used in the pharmaceutical and cosmetic fields. As a biosurfactant, fatty acid amides have the advantage of being a surfactant that is renewable and environmentally friendly. This study aimed to obtain biosurfactants by applying the Response Surface Method and determining the effect of adding lipase, amine, and the yield of fatty acid amide. The results showed that the addition of amines and temperature would increase the yield of the two amides produced. However, the effect of temperature is more significant than the addition of amines. The optimal results obtained in the synthesis of diethanolamide were obtained when using enzyme 11-12%, diethanolamine 2-2.5 molar, and temperature 45-49°C, and in the synthesis of glucosamide, optimal glucosamide yield was obtained when using enzyme 9-10%, glucosamine 2-3 molar, and a temperature of 40-45°C.