DefinePK

Abstract

Diabetic patients having ischemic heart disease presenting at Jinnah Postgraduate Medical Centre Karachi were included in study to seethe effect of magnesium deficiency associated with diabetes mellitus. Comparative study was carried out in total of 180 diabetic patients,90 diabetic patients without ischemic heart disease events, 90 diabetic patient but having ischemic heart disease events, out of these 90,30having attack of acute myocardial infarction, 30 having angina pectoris and 30 having unstable angina. Serum magnesium was significantlylow (p<0.001) & this correlates inversely with serum glucose, urinary magnesium & HBA1c (p<0.001) which are significantly increased(p<0.001) in patients having an events of ischemic heart disease. Serum Triglycerides, LDL-cholesterol significantly increased (p<0.001)and total cholesterol also significantly increased (p<0.01) while serum HDL-cholesterol significantly decreased (p<0.001) in diabetic patientshaving events of ischemic heart disease.