DefinePK

Abstract

Present study evaluated a new factor i.e. effect of coronary artery disease (CAD) duration on plasma lipidsand lipoproteins concentration. 105 patients of atherosclerotic CAD were divided as: group-A (n=59) havingCAD duration 1 year, group=-B (n=25) and group-C (n=21) having CAD duration 3 years. In group-A, 79%patients had positive history of vegetable oil use, group-B, 68% and in group-C, 61% patients have positivehistory of vegetable oil use in their diet after onset of CAD symptomatology. Results showed that totalcholesterol (TC), LDL and LDL-C which were significantly raised in group-A and B, become nonsignificantlyraised levels in group-C when each group compared with control subject (n=35) while exceptsignificantly decreased levels (p<0.02) of HDL2-C in group-B, all other parameters (TC, triglycerides, LDL,LDL-C, VLDL-C, THDL-C and HDL-C) showed non-significant difference when compared with group-A.Non-significant difference in levels also seen in group-C when compared with group- A. Study concludedthat after 3 years of CAD duration TC, LDL and LDL-C levels were decreased. However, this effect maybe depended upon vegetable oil use. While effect of CAD duration on HDL-C levels remained controversial.