THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES

Article Information

Title: THE EFFECT OF VITAMIN D SUPPLEMENTATION ON GESTATIONAL DIABETES

Authors: Syeda Ayesha Gillani, Saima Naz, Samreen Latif, Samina Khurshid

Journal: The Research of Medical Science Review

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31

Publisher: Innovative Education Research Institute

Country: Pakistan

Year: 2024

Volume: 2

Issue: 3

Language: English

Keywords: Glycated HemoglobinGestational Diabetes Mellitus,Oral glucose tolerance test,homeostasis model assessment-estimated insulin resistance

Abstract

Introduction: In view of the growing prevalence of gestational diabetes mellitus (GDM), a great deal of study has been done to determine the link between vitamin insufficiency and GDM. All the same, Pakistan has not generated many clinical research studies.&nbsp;Objective: The goal of this study is to determine how vitamin D supplementation impacts the GDM and vitamin D insufficiency in pregnant women.&nbsp;Method: During patients' prenatal checks at the hospital, information was gathered from them using a self-made questionnaire. Serum vitamin D testing was done on patients aged 18 to 40 who were diagnosed with gestational diabetes between the 24th and 28th week of pregnancy. Group A and B were formed from 106 GDM patients who were vitamin D insufficient. Group B, the control group, received no therapy for six weeks while Group A received an interventional dosage of vitamin D (50,000 IU) twice at two-week intervals. Group A received only two doses totaling fifty thousand units of dosage. The two groups' serum FBS, HbA1c, and vitamin D levels were compared.&nbsp;Findings: Following the intervention, there was a significant drop in HbA1c (5.764), a rise in Vit D (23.70 ng/mL), and a change in FBS (97.55 mg/dL),Results: According to descriptive data. Significant differences were verified by a Mann-Whitney U test, which&nbsp;rejected the null hypothesis for all variables (p &lt; 0.05).
Conclusion: The group that received the intervention showed better results than the control group, including better glycemic control and higher levels of vitamin D. These results highlight the intervention's potential effectiveness in managing gestational diabetes and&nbsp;highlight how important it is to optimal mother health.&nbsp;

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Research Objective

To determine how vitamin D supplementation impacts gestational diabetes mellitus (GDM) and vitamin D insufficiency in pregnant women.

Methodology

A quasi-experimental design was employed. Data was collected from 106 pregnant women diagnosed with gestational diabetes and vitamin D insufficiency between the 24th and 28th week of pregnancy. Participants were aged 18-40. They were divided into two groups: Group A (intervention group) received 50,000 IU of vitamin D twice at two-week intervals for six weeks, and Group B (control group) received no vitamin D therapy. Serum FBS, HbA1c, and vitamin D levels were compared between the two groups.

Methodology Flowchart

                        graph TD
    A[Recruit Pregnant Women with GDM and Vitamin D Insufficiency] --> B[Divide into InterventionA and ControlB Groups];
    B --> C[Administer Vitamin D Supplementation to Group A for 6 Weeks];
    B --> D[No Vitamin D Supplementation for Group B];
    C --> E[Collect Data: Serum FBS, HbA1c, Vitamin D Levels];
    D --> E;
    E --> F[Analyze Data using Mann-Whitney U Test];
    F --> G[Compare Results between Groups];
    G --> H[Draw Conclusions];

Discussion

The study suggests a significant correlation between GDM and vitamin D insufficiency. The intervention group demonstrated improved glycemic control and higher vitamin D levels compared to the control group, indicating the potential effectiveness of vitamin D supplementation in managing gestational diabetes. The discussion also highlights the importance of considering other factors and the need for further research to determine optimal dosages and long-term effects.

Key Findings

Following the six-week intervention, Group A showed a significant drop in HbA1c (mean 5.660), a rise in Vitamin D levels (mean 31.89 ng/mL), and a change in FBS (mean 89.58 mg/dL) compared to baseline. The Mann-Whitney U test indicated significant differences between the groups for all variables (p < 0.05).

Conclusion

Vitamin D supplementation showed positive effects on glycemic control and vitamin D status in pregnant women with gestational diabetes. The intervention group exhibited better outcomes than the control group, supporting the hypothesis that vitamin D supplementation is beneficial for managing GDM and improving maternal health.

Fact Check

1. Sample Size: The study calculated a sample size of 106 participants (53 in each group).
2. Intervention Dosage: The intervention group received a total dosage of 50,000 IU of vitamin D twice over six weeks.
3. Statistical Significance: The Mann-Whitney U test results for HbA1c, FBS, and Vitamin D showed p-values of .003, .000, and .000 respectively, all below the significance level of 0.05, indicating statistically significant differences.

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