DefinePK

Research Objective

To assess the impact of local infiltration, both with and without tranexamic acid, on blood loss during cleft palate surgery.

Methodology

A total of 60 patients aged 9 to 60 months with congenital cleft palate were included. Patients were divided into two groups: Group I received TXA infiltration, and Group II received infiltration without TXA. The surgical repair was performed using Sommerlad's technique after 10 minutes of infiltration. Intra-operative blood loss was measured. Data analysis was performed using SPPS v25, with an independent sample t-test used to compare blood loss, considering a p-value of 0.05 as significant.

Methodology Flowchart

                        graph TD;
    A[Recruit 60 patients 9-60 months with cleft palate] --> B[Divide into two groups: TXA infiltrationGroup I vs. No TXA infiltrationGroup II];
    B --> C[Perform TXA or control infiltration];
    C --> D[Wait 10 minutes];
    D --> E[Perform cleft palate repair using Sommerlad's technique];
    E --> F[Measure intra-operative blood loss];
    F --> G[Analyze data using SPPS v25 and independent t-test];
    G --> H[Draw conclusions on TXA's effect on blood loss];                    

Discussion

Blood loss is a critical parameter in pediatric surgeries due to the limited circulatory volume of these patients. Tranexamic acid (TXA) is a safe antifibrinolytic agent that effectively reduces intraoperative blood loss. The study found a significant positive effect of TXA infiltration in reducing blood loss during cleft palate repair, which can decrease the need for hemostatic measures and blood transfusions.

Key Findings

The mean operative blood loss in the TXA group was 58.6±12.7 ml, while in the control group, it was 83.8±16.3 ml, with a p-value <0.0001, indicating a significant reduction in blood loss with TXA infiltration.

Conclusion

TXA infiltration before cleft palate repair surgery significantly reduces intra-operative blood loss, thereby minimizing the need for additional hemostatic measures and post-operative blood transfusions.

Fact Check

* Number of patients: 60 patients were included in the study.
* Age range: Patients were between 9 and 60 months old.
* Mean blood loss in TXA group: 58.6±12.7 ml.
* Mean blood loss in control group: 83.8±16.3 ml.

Mind Map