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Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis

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Title: Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis

Authors: Jing Xie, Lu Zhang, Ning Gan

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2025

Volume: 75

Issue: 1

Language: en

DOI: 10.47391/JPMA.11088

Keywords: Risk FactorsLactate dehydrogenaseD-Dimersevere traumatic brain injuryNeuron-specific enolase

Categories
Brain Injury (6) Prognostic Biomarkers (3) Neurosurgery (1650) Trauma (525) Logistic Regression (12)

Abstract

The retrospective study was conducted at Baoding No.1 Central Hospital, China, and comprised data from July 2021 to January 2023, and aimed at exploring the relationship of neuron-specific enolase, D-dimer and lactate dehydrogenase with prognosis in patients with serous traumatic brain injury. Data of 100 patients was categorised into favourable prognosis group A having 50(50%) patients and unfavourable prognosis group B having 50(50%) patients, and was compared with as many healthy controls in group C. Increase in neuron-specific enolase, D-dimer and lactate dehydrogenase concentrations was significantly elevated in groups A and B compared to group C (p<0.05), and in group B compared to group A (p<0.05).
Key Words: Severe traumatic brain injury, Neuron-specific enolase, D-dimer, Lactate dehydrogenase, Risk factors.

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