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Title: Comparison of potential plasma biomarkers in Alzheimer’s disease and neurodegenerative dementias in Pakistani population
Authors: Tehniat Faraz Ahmed, Fauzia Imtiaz, Uzma Zaman, Affan Ahmed, Naila Shahbaz
Journal: Journal of Pakistan Medical Association
Publisher: Pakistan Medical Association.
Country: Pakistan
Year: 2023
Volume: 73
Issue: 10
Language: en
DOI: 10.47391/JPMA.7286
Keywords: Biomarkerstau proteinsAlzheimer diseaseAmyloid beta peptidesNeurofilament proteins
This study aimed to compare the mean plasma levels of Amyloid B42, Phosphorylated Tau and Neurofilament Light chain in patients diagnosed with Alzheimer’s Clinical Syndrome (ACS), and other neurodegenerative dementias to find affordable and less-invasive means of diagnosing Alzheimer’s disease (AD) early in its course.
Blood samples of 36 subjects presenting with cognitive decline to the neurology OPDs of Dow and Civil hospitals, Karachi, were centrifuged, and plasma was stored at 80C. Before analysis, it was thawed at 4C and protein levels were measured through ELISA.
Two-thirds of the patients were females but age distribution across both the groups was not significantly different (p 0.21). No difference was observed in the mean plasma concentrations of AB42, P-Tau, and NFL between the two groups (p-values 0.78 and 0.27 and 0.09 respectively).
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