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Problem to solution; from mammalian skin grafts to renal allograft rejection: a tale of 66 years of evolution of our understanding

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Title: Problem to solution; from mammalian skin grafts to renal allograft rejection: a tale of 66 years of evolution of our understanding

Authors: Murtaza Dhrolia, Aasim Ahmad

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2023

Volume: 73

Issue: 6

Language: en

DOI: 10.47391/JPMA.6600

Keywords: EvolutionAllograft rejectionRenal Transplantationimmunosuppressant

Categories
Allograft Rejection (1) Transplantation (240) Renal Transplantation (16) Immunology (7543) Evolution (53)

Abstract

The first successful kidney transplant was done in 1954, and it remains the best option for those with failed kidneys. However, the recipient’s immune system remains the most formidable barrier to transplantation, leading to rejection. Rejection continues to be the most important reason of graft malfunction and chronic renal allograft dysfunction and remains a challenge to date for successful transplant survival. The current narrative review was planned to find the best possible solution to the problem from among the different solutions presented in literature related to allograft rejection since 1954.
Key Words: Evolution, Renal transplantation, Allograft rejection, Immunosuppressant.

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