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Tumour sink effect on 68Ga-PMSA PET/CT: A case of diffuse metastatic disease of prostate cancer

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Title: Tumour sink effect on 68Ga-PMSA PET/CT: A case of diffuse metastatic disease of prostate cancer

Authors: Sharjeel Usmani, Khulood Al Riyami, Sofiullah Abubakar, Anjali Jain, Asiya Al Busaidi

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2023

Volume: 73

Issue: 6

Language: en

DOI: 10.47391/JPMA.23-45

Keywords: PET/CT68Ga-PSMA PET/CT tumor sink effect177Lu-PSMA-RLT

Categories
Metastasis (30) PET/CT (4) Prostate Cancer (41) Nuclear Medicine (308) Oncology (10297)

Abstract

68Ga-PMSA imaging has revolutionized both diagnosis and radioligand therapy selection in patients with metastatic prostate cancer. We report a case of a 59-year-old recently diagnosed prostate cancer with high PSA level pf >2000ng/ml referred for 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT showed diffuse intense tracer uptake throughout the axial and appendicular skeleton with significantly lower uptake of 68Ga-PSMA in normal organs in a configuration of “tumour sink effect”. Findings are in keeping with diffuse skeletal infiltration and suspected marrow infiltration. Given the extensive nature of bone disease and pattern, 177Lu-PSMA-targetted radioligand therapy was thought to be more appropriate in a given situation with a favourable toxicity profile.
Keywords: 68Ga-PSMA PET/CT; tumor sink effect; 177Lu-PSMA-RLT; PET/CT

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