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68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

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Title: 68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

Authors: Sharjeel Usmani, Anjali Jain, Syed Furqan Hashmi, Layth Mula-Hussain, Khulood Al Riyami, Sofiullah Abubakar, Muhammad Shahzad Shamim

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2023

Volume: 73

Issue: 6

Language: en

DOI: 10.47391/JPMA.23-44

Keywords: MeningiomaPET/CT68Ga-DOTA PET/CT177Lu-DOTATATEradiotherapy planning

Categories
PET/CT (4) Radiotherapy Planning (1) Meningioma (1) Nuclear Medicine (308) Oncology (10297)

Abstract

Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTA-peptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves inter-observer variability and appears to be particularly promising for RT planning. The potential strength of 68Ga-DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.
Keywords: 68Ga-DOTA PET/CT; Meningioma; 177Lu-DOTATATE; PET/CT; radiotherapy planning.

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