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How to reset metabolic setpoint in obesity management

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Title: How to reset metabolic setpoint in obesity management

Authors: Sanjay Kalra , Saurabh Arora, Nitin Kapoor

Journal: Journal of Pakistan Medical Association

HEC Recognition History
Category From To
Y 2024-10-01 2025-12-31
X 2023-07-01 2024-09-30
X 2022-07-01 2023-06-30
X 2021-07-01 2022-06-30
X 2020-07-01 2021-06-30
W 2012-07-01 2020-06-30
X 2011-05-13 2012-06-30
Y 1900-01-01 2005-06-30

Publisher: Pakistan Medical Association.

Country: Pakistan

Year: 2022

Volume: 72

Issue: 2

Language: en

DOI: 10.47391/JPMA.22-37

Categories
Dietary Interventions (26) Metabolic Setpoint (1) Obesity (578) Metabolism (698) Weight Management (17)

Abstract

The metabolic setpoint theory is based upon the premise that there is a barohomeostatic mechanism in humans which maintains weight within a predetermined range. This is viewed as an obstacle to weight loss, but can also be considered an opportunity to reset the barometabolic setpoint. This expert clinical opinion piece shares pragmatic suggestions on how to achieve this. Initiating with monotherapy, titrating dosage gradually, inter-changing treatment if needed, troubleshooting where necessary and intensifying slowly to combination therapy help reset the barometabolic homeostatic range.
Keywords: Barocrinology, GLP1RA, Intensive behavioural therapy, Liraglutide, Overweight, Obesity, Semaglutide.

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