DefinePK

Abstract

Objective: To compare the efficacy of intravenous midazolam and diazepam in the management of status epilepticus seizures in children.
Method: The comparative study was conducted in the paediatric neurological emergency unit of The Children’s Hospital and the Institute Of Child Health, Multan, Pakistan, from December 15, 2018, to May 14, 2019, and comprised paediatric patients of status epilepticus seizures whi were divided into Diazepam and Midazolam groups.  Data was analysed using Graph-Pad Prism 5.
Results: Of the 164 patients, 82(50%) were in each of the two groups. There was no significant difference between the groups in terms of weight, age, residence area of patients and mean duration of seizures (p>0.05). Status epilepticus seizures subsided after intravenous midazolam administration in 77(93.90%) cases, while success in the diazepam group 64(78.05%) (p<0.05). Mean time taken by midazolam to halt seizures was significantly shorter than diazepam (p<0.05) and less cases of treatment failure were observed with intravenous midazolam (p<0.05). Somnolence was observed after diazepam administration in 47(57.3%) cases (p=0.0001).
Conclusion: Intravenous midazolam was found to be superior in efficacy than intravenous diazepam in controlling status epilepticus seizures.
Key Words: Diazepam, Midazolam, Status epilepticus, Seizures