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Abstract

Objective: To assess and compare the occurrence of hypotension and the demand for vasopressors inparturients undertaking spinal anesthesia during cesarean delivery, distinguishing between those whoreceived crystalloid preload and those who received coload.Study Design: Quasi-experimental study.Place and Duration of Study: The study was conducted at Department of Anesthesiology, Combined MilitaryHospital (CMH) Rawalpindi, Pakistan for two years from July 2021 to July 2023.Methods: Fifty-four parturients, categorized as ASA II, with full-term singleton gestations planned for electivecesarean delivery under spinal anesthesia, were randomly divided into two groups. Both groups received15ml/kg of crystalloid as a preload and a coload. The initial readings of heart rate and arterial pressures wereevaluated before spinal induction and subsequently at one minute intervals until the completion of theoperation. Intravenous ephedrine was administered to manage hypotension, characterized by a more than20% reduction in systolic blood pressure.Results: The group receiving preload demonstrated notably lower values in both the minimum recordedsystolic and mean blood pressure, as well as in the reduction of systolic and mean blood pressure from thebaseline, in comparison to the coload group (P < 0.001). The occurrence of hypotension in the preload groupwas significantly elevated at 92.6%, indicating a statistically significant difference (P = 0.039) when compared tothe coload group, where the incidence was 67%. Additionally, the mean ephedrine dose requirement wassignificantly higher in the preload group at 12.2 ± 5.9 mg (P = 0.029) compared to the coload group, which had amean ephedrine dose requirement of 8.3 ± 6.8 mg. There were no significant differences between neonataloutcomes, such as APGAR score and blood gases, between the two groups.Conclusion: The adoption of the crystalloid coload method proved more effective than the preload techniquein reducing the incidence of intraoperative maternal hypotension and decreasing the necessity forvasopressors in parturients undergoing cesarean delivery.
How to cite this: Zahid TR, Hinna R, Farooq U, Waraich AA, Bashir R, Ali I. Effect of Crystalloid Administration Timing On Hypotension in Spinal Anesthesia for Cesarean Delivery: Preload Versus Coload: A Study at a Tertiary Care Hospital in Rawalpindi. Life and Science. 2024; 5(4): 491-496. doi: http://doi.org/10.37185/LnS.1.1.468