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Abstract

Trauma is a major cause of massive haemorrhage, which accounts for six out of ten trauma-related early deaths. Maintenance of circulation in a massive bleeding as a result of injury is a big challenge. This includes not only the control of on-going blood loss but the coagulopathy, that may result from transfusion, and hypothermia. On-going research on the subject has improved our understanding about the pathophysiology that has resulted in development of new guidelines and treatment protocols for crystalloid and massive blood transfusion, a restricted and goal directed resuscitative approach.1   ...............