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Abstract

Objective
To assess the effect of treatment with the androgen testosterone undecanoate on seminal variables and frequency of pregnancy in subfertile men with idiopathic oligoasthenozoospermia.
Study design
Descriptive Case Series.
Place & Duration of study
Department of Obstetrics & Gynaecology, Bahawal Victoria Hospital & Civil Hospital Bahawalpur, from December 2015 to December 2018.
Methodology
Men, aged 18-50 years, who visited the outpatient department with the complaint of infertility were enrolled in this study. They were given testosterone undecanoate 40mg t.i.d for 3 months and followed up for another 3 months without treatment. Seminal analysis was done after 3 days of abstinence, before and after treatment as well as at the end of a 3-month treatment-free follow up period.
Results
A total of 1800 patients were included. Asthenozoospermia was the most common abnormality, found in 76.1% (n=1370) of the sample. The baseline mean sperm concentration was 16.65 +7.14x106/ml and the mean percentage of progressively motile sperm was 17.21+ 13.52%. These parameters increased to 54.28 + 20.11x106/ml and 35.07+ 16.39% at the end of 3-month follow up period, respectively. Pregnancies were achieved in 469 (26.05%) female partners of male patients during the study period.
Conclusion
Testosterone undecanoate has tangible positive effects on seminal parameters leading to conceptions among subfertile couples.
Key words
Male Infertility, Oligozoospermia, Asthenozoospermia, Testosterone undecanoate.